Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0H6YF
|
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| Former ID |
DIB018557
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| Drug Name |
2-iodo-melatonin
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| Synonyms |
2-iodomelatonin; 2-I-MLT
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C13H15IN2O2
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| InChI |
InChI=1S/C13H15IN2O2/c1-8(17)15-6-5-10-11-7-9(18-2)3-4-12(11)16-13(10)14/h3-4,7,16H,5-6H2,1-2H3,(H,15,17)
|
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| InChIKey |
FJDDSMSDZHURBJ-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
4501994, 10236748, 11111317, 11113672, 14925812, 17405172, 26751858, 29296844, 47276710, 47276711, 47870806, 49859761, 50139481, 50139486, 53777716, 57339130, 79348311, 81055040, 85087006, 85208909, 85788614, 91746217, 92304012, 99444661, 103205947, 103837751, 104398177, 117539624, 124749855, 124880415, 124880416, 125713001, 126726217, 127854796, 134222428, 134341338, 135072530, 135651396, 135697865, 140308831, 142167520, 160969243, 162022733, 163129227, 179293782, 196372197, 226526019, 241176901, 241181856, 241377456
|
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| Target and Pathway | |||||
| Target(s) | Melatonin receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Circadian entrainment | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1343). | ||||
| REF 2 | Characterization of a retinal melatonin receptor. J Pharmacol Exp Ther. 1985 Aug;234(2):395-401. | ||||
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