Drug Information

Drug General Information
Drug ID
D0H5NX
Former ID
DCL000290
Drug Name
TOP-53
Synonyms
Top 53; (5R,5aR,8aR,9S)-9-[2-[2-dimethylaminoethyl(methyl)amino]ethyl]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-6-one dihydrochloride
Drug Type
Small molecular drug
Indication Lung metastatic tumors [ICD9: 162; ICD10:C33, C34] Discontinued in Phase 1 [545776]
Company
Taiho Pharmaceutical Co Ltd
Structure
Download
2D MOL

3D MOL
Formula
C28H38Cl2N2O7
Canonical SMILES
CN(C)CCN(C)CCC1C2COC(=O)C2C(C3=CC4=C(C=C13)OCO4)C5=CC(=<br />C(C(=C5)OC)O)OC.Cl.Cl
InChI
1S/C28H36N2O7.2ClH/c1-29(2)8-9-30(3)7-6-17-18-12-21-22(37-15-36-21)13-19(18)25(26-20(17)14-35-28(26)32)16-10-23(33-4)27(31)24(11-16)34-5;;/h10-13,17,20,25-26,31H,6-9,14-15H2,1-5H3;2*1H/t17-,20-,25-,26+;;/m1../s1
InChIKey
AOGFGBUUQUKBHV-LICKGGAWSA-N
CAS Number
CAS 147238-98-0
PubChem Compound ID
6918225
PubChem Substance ID
12014725, 17194752, 43529611, 50704034, 57371843, 114787641, 134338946
Target and Pathway
Target(s) DNA topoisomerase II Target Info Modulator [535107]
References
Ref 545776Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004663)
Ref 535107DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action. Biochemistry. 2001 Jan 23;40(3):712-8.

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