Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D0H3XB
|
||||
Former ID |
DIB002313
|
||||
Drug Name |
TULOPAFANT
|
||||
Synonyms |
RP-59227; Tulopafant < Rec INN >; (R)-(+)-3'-Benzoyl-3-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carboxanilide; (R)-(+)-N-(3-Benzoylphenyl)-3-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carboxamide; 59227-RP
|
||||
Drug Type |
Small molecular drug
|
||||
Indication | Cardiac arrhythmias [ICD9: 427; ICD10:I47-I49] | Terminated | [544829] | ||
Structure |
Download2D MOL |
||||
Formula |
C25H19N3O2S
|
||||
Canonical SMILES |
O=C(Nc1cccc(c1)C(=O)c2ccccc2)c3ccn4[C@H](SCc34)c5cccnc5
|
||||
InChI |
1S/C25H19N3O2S/c29-23(17-6-2-1-3-7-17)18-8-4-10-20(14-18)27-24(30)21-11-13-28-22(21)16-31-25(28)19-9-5-12-26-15-19/h1-15,25H,16H2,(H,27,30)/t25-/m1/s1
|
||||
InChIKey |
PQQFNXGONTVQLM-RUZDIDTESA-N
|
||||
CAS Number |
CAS 116289-53-3
|
||||
PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [531635], [534023] | |
NetPath Pathway | IL5 Signaling Pathway | ||||
Leptin Signaling Pathway | |||||
References | |||||
Ref 531635 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | ||||
Ref 534023 | Tulopafant, a PAF receptor antagonist, increases capillary patency and prolongs survival in discordant cardiac xenotransplants. J Lipid Mediat. 1993 May;7(1):79-84. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.