Drug General Information
Drug ID
D0H3UW
Former ID
DIB018006
Drug Name
compound 1
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Clinical trial [528175], [541676]
Formula
C26H24N6O7
InChI
InChI=1S/C26H24N6O7/c27-23(28)12-2-3-18-19(8-12)32-24(31-18)17-7-13(14(25(37)38)9-21(34)35)6-16(22(17)36)15-5-11(1-4-20(15)33)10-30-26(29)39/h1-8,14,31-33H,9-10H2,(H3,27,28)(H,34,35)(H,37,38)(H3,29,30,39)/b24-17+
InChIKey
VPCHMCAFZYYMSK-JJIBRWJFSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Coagulation factor VII Target Info Inhibitor [528175]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Angiogenesis
Blood coagulation
PathWhiz Pathway Coagulation
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
Extrinsic Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
Circadian Clock
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 528175Efforts toward oral bioavailability in factor VIIa inhibitors. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3829-32. Epub 2006 May 2.
Ref 541676(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6552).
Ref 528175Efforts toward oral bioavailability in factor VIIa inhibitors. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3829-32. Epub 2006 May 2.

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