Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0H3JH
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| Former ID |
DIB006117
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| Drug Name |
CGI-1316
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| Synonyms |
CGI-1316; CGI-1746; CGI-2233; CGI-2815; CGI-3130; CGI-560; CGI-676; Btk inhibitors (autoimmune disease/inflammatory disease); Btk inhibitors (autoimmune disease/inflammatory disease), CGI Pharmaceuticals; Btk inhibitors (autoimmune disease/inflammatory disease), Cellular Genomics; Btk inhibitors (autoimmune disease/inflammatory disease), Gilead
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| Drug Type |
Small molecular drug
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| Indication | Autoimmune diabetes [ICD10:E08-E13] | Investigative | [1] | ||
| Company |
CGI Pharmaceuticals Inc
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| Structure |
|
Download2D MOL |
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| Formula |
C34H37N5O4
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| InChI |
InChI=1S/C34H37N5O4/c1-22-27(7-6-8-28(22)37-31(40)23-9-13-25(14-10-23)34(2,3)4)29-21-38(5)33(42)30(36-29)35-26-15-11-24(12-16-26)32(41)39-17-19-43-20-18-39/h6-16,21H,17-20H2,1-5H3,(H,35,36)(H,37,40)
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| InChIKey |
JIFCFQDXHMUPGP-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Tyrosine-protein kinase BTK | Target Info | Inhibitor | [2] | |
| KEGG Pathway | NF-kappa B signaling pathway | ||||
| Osteoclast differentiation | |||||
| Platelet activation | |||||
| B cell receptor signaling pathway | |||||
| Fc epsilon RI signaling pathway | |||||
| Primary immunodeficiency | |||||
| PANTHER Pathway | B cell activation | ||||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | ||||
| BCR signaling pathway | |||||
| FAS (CD95) signaling pathway | |||||
| Class I PI3K signaling events | |||||
| EPO signaling pathway | |||||
| PathWhiz Pathway | Fc Epsilon Receptor I Signaling in Mast Cells | ||||
| Reactome | MyD88:Mal cascade initiated on plasma membrane | ||||
| Regulation of actin dynamics for phagocytic cup formation | |||||
| DAP12 signaling | |||||
| FCERI mediated Ca+2 mobilization | |||||
| MyD88 deficiency (TLR2/4) | |||||
| IRAK4 deficiency (TLR2/4) | |||||
| RHO GTPases Activate WASPs and WAVEs | |||||
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | |||||
| WikiPathways | Kit receptor signaling pathway | ||||
| MyD88:Mal cascade initiated on plasma membrane | |||||
| Signaling by the B Cell Receptor (BCR) | |||||
| DAP12 interactions | |||||
| B Cell Receptor Signaling Pathway | |||||
| TSLP Signaling Pathway | |||||
| Regulation of toll-like receptor signaling pathway | |||||
| IL-5 Signaling Pathway | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8066). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1948). | ||||
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