Drug Information

Drug General Information
Drug ID
D0H2MF
Former ID
DNC010894
Drug Name
PF-02367982
Drug Type
Small molecular drug
Indication Endometriosis [ICD9: 617; ICD10:N80] Investigative [530880]
Structure
Download
2D MOL

3D MOL
Formula
C20H21N3O2
Canonical SMILES
CNC(=O)CN1C=C(C(=C1C2CC2)OC3=CC=C(C=C3)C#N)C4CC4
InChI
1S/C20H21N3O2/c1-22-18(24)12-23-11-17(14-4-5-14)20(19(23)15-6-7-15)25-16-8-2-13(10-21)3-9-16/h2-3,8-9,11,14-15H,4-7,12H2,1H3,(H,22,24)
InChIKey
AALHNBNOUAEYHF-UHFFFAOYSA-N
PubChem Compound ID
46889848
Target and Pathway
Target(s) Progesterone receptor Target Info Inhibitor [530880]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 530880Bioorg Med Chem Lett. 2010 Jun 1;20(11):3384-6. Epub 2010 Apr 13.Optimisation of a pyrazole series of progesterone antagonists; Part 1.
Ref 530880Bioorg Med Chem Lett. 2010 Jun 1;20(11):3384-6. Epub 2010 Apr 13.Optimisation of a pyrazole series of progesterone antagonists; Part 1.

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