TTD | Drug: D0H1EB

Drug General Information
Drug ID	D0H1EB
Former ID	DIB018908
Drug Name	ATLa2
Synonyms	ATL analog [15-epi-16-(para-fluoro)-phenoxy-LXA4]
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540331]
Structure		Download 2D MOL
Formula	C23H29FO5
InChI	InChI=1S/C23H29FO5/c1-18(17-29-20-15-13-19(24)14-16-20)9-6-4-2-3-5-7-10-21(25)22(26)11-8-12-23(27)28/h2-7,9-10,13-16,18,21-22,25-26H,8,11-12,17H2,1H3,(H,27,28)/b4-2-,5-3+,9-6+,10-7+/t18-,21+,22-/m0/s1
InChIKey	SGFIFYSIHRWSCE-LLXPRBAESA-N
PubChem Compound ID	73755048
PubChem Substance ID	178100400
Target and Pathway
Target(s)	FMLP-related receptor I	Target Info	Agonist	[527021]
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome	G alpha (q) signalling events
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540331	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3383).
Ref 527021	Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo. J Med Chem. 2004 Apr 8;47(8):2157-65.

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Drug Information