Drug Information

Drug General Information
Drug ID
D0GR5L
Former ID
DNC003681
Drug Name
AL-43
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526567]
Structure
Download
2D MOL

3D MOL
Formula
C23H25NO2
Canonical SMILES
CC1=CC(NC2=C1C3=C(C=C2)C4=C(C=CC=C4OC)OC3CC=C)(C)C
InChI
1S/C23H25NO2/c1-6-8-18-22-15(21-17(25-5)9-7-10-19(21)26-18)11-12-16-20(22)14(2)13-23(3,4)24-16/h6-7,9-13,18,24H,1,8H2,2-5H3
InChIKey
CZSDJYXNNJQXBB-UHFFFAOYSA-N
PubChem Compound ID
9906282
Target and Pathway
Target(s) mRNA of glucocorticoid receptor Target Info Inhibitor [527002]
mRNA of androgen receptor Target Info Inhibitor [526567]
Progesterone receptor Target Info Inhibitor [526567]
Mineralocorticoid receptor Target Info Inhibitor [526567]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancerhsa04114:Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04960:Aldosterone-regulated sodium reabsorption
NetPath Pathway IL2 Signaling Pathway
TCR Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY networkanthraxpathway:Cellular roles of Anthrax toxin
PathWhiz Pathway Kidney Function
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expressionR-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-1251985:Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathwayWP34:Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP554:ACE Inhibitor Pathway
References
Ref 526567J Med Chem. 2003 Mar 13;46(6):1016-30.Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Ref 526567J Med Chem. 2003 Mar 13;46(6):1016-30.Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Ref 527002Bioorg Med Chem Lett. 2004 Apr 5;14(7):1721-7.Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.