Drug Information
Drug General Information | |||||
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Drug ID |
D0GR2J
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Former ID |
DIB003429
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Drug Name |
Idoxifene
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Synonyms |
CB-7432; SB-223030
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Drug Type |
Small molecular drug
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Indication | Breast cancer [ICD9: 174, 175; ICD10:C50] | Discontinued in Phase 3 | [545487] | ||
Company |
Institute of Cancer Research UK
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Structure |
Download2D MOL |
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Formula |
C28H30INO
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Canonical SMILES |
C(=C(\c1ccccc1)/CC)(/c1ccc(cc1)I)\c1ccc(cc1)OCCN1CCCC1
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CAS Number |
CAS 116057-75-1
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Estrogen receptor | Target Info | Modulator | [534760] | |
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
Signaling events mediated by HDAC Class II | |||||
Plasma membrane estrogen receptor signaling | |||||
LKB1 signaling events | |||||
Regulation of Telomerase | |||||
ATF-2 transcription factor network | |||||
AP-1 transcription factor network | |||||
FOXM1 transcription factor network | |||||
Validated nuclear estrogen receptor alpha network | |||||
Signaling mediated by p38-alpha and p38-beta | |||||
FOXA1 transcription factor network | |||||
References |
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