| Drug General Information |
| Drug ID |
D0GL9I
|
| Former ID |
DNC002426
|
| Drug Name |
N-Omega-Hydroxy-L-Arginine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C6H14N4O3
|
| Canonical SMILES |
C(CC(C(=O)O)N)CN=C(N)NO
|
| InChI |
1S/C6H14N4O3/c7-4(5(11)12)2-1-3-9-6(8)10-13/h4,13H,1-3,7H2,(H,11,12)(H3,8,9,10)/t4-/m0/s1
|
| InChIKey |
FQWRAVYMZULPNK-BYPYZUCNSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
8221, 822027, 826133, 826385, 835429, 836346, 837633, 837636, 837639, 7888069, 11111278, 14716265, 15120787, 15219835, 15219836, 29214873, 29214874, 29214876, 29214984, 29304069, 46392149, 46506099, 47425378, 50111096, 57340642, 77796611, 85256779, 85256786, 85256793, 87557060, 103069625, 103084532, 103568236, 104419587, 117541441, 124749859, 127341413, 127341414, 127886628, 135079346, 137244979, 140091124, 144080325, 160966291, 184588420, 191112404, 224590479, 226769737, 250136849
|
| Target and Pathway |
| Target(s) |
Nitric-oxide synthase, endothelial |
Target Info |
Inhibitor |
[1]
|
|---|
| Nitric oxide synthase, inducible |
Target Info |
Inhibitor |
[1]
|
| Nitric-oxide synthase, brain |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
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KEGG Pathway
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Arginine and proline metabolism
|
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Metabolic pathways
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Calcium signaling pathway
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cGMP-PKG signaling pathway
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HIF-1 signaling pathway
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Sphingolipid signaling pathway
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PI3K-Akt signaling pathway
|
|
VEGF signaling pathway
|
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Platelet activation
|
|
Estrogen signaling pathway
|
|
Oxytocin signaling pathwayhsa00220:Arginine biosynthesis
|
|
Peroxisome
|
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Salmonella infection
|
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Pertussis
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Leishmaniasis
|
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Chagas disease (American trypanosomiasis)
|
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Toxoplasmosis
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Amoebiasis
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Tuberculosis
|
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Pathways in cancer
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Small cell lung cancerhsa00330:Arginine and proline metabolism
|
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Phagosome
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Circadian entrainment
|
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Long-term depression
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Salivary secretion
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)
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NetPath Pathway
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Wnt Signaling PathwayNetPath_13:IL1 Signaling Pathway
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IL2 Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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Endothelin signaling pathway
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Interleukin signaling pathway
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PI3 kinase pathway
|
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VEGF signaling pathwayP06959:CCKR signaling map ST
|
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Pathway Interaction Database
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Plasma membrane estrogen receptor signaling
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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Angiopoietin receptor Tie2-mediated signaling
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Thromboxane A2 receptor signaling
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SHP2 signaling
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2
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PAR1-mediated thrombin signaling eventsil12_2pathway:IL12-mediated signaling events
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Alpha9 beta1 integrin signaling events
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ATF-2 transcription factor network
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IL23-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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HIF-1-alpha transcription factor network
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PathWhiz Pathway
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Arginine and Proline Metabolism
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Reactome
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ROS production in response to bacteria
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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eNOS activation
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Nitric oxide stimulates guanylate cyclase
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VEGFR2 mediated vascular permeabilityR-HSA-1222556:ROS production in response to bacteria
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Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
|
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WikiPathways
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ACE Inhibitor Pathway
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EGF/EGFR Signaling Pathway
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Myometrial Relaxation and Contraction Pathways
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JAK/STAT
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Corticotropin-releasing hormone
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AGE/RAGE pathway
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Endothelin Pathways
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Leptin signaling pathway
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Effects of Nitric Oxide
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Metabolism of nitric oxide
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AngiogenesisWP619:Type II interferon signaling (IFNG)
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Spinal Cord Injury
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Effects of Nitric OxideWP727:Monoamine Transport
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Amyotrophic lateral sclerosis (ALS)
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Alzheimers Disease
|
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Serotonin Transporter Activity
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| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
