Drug General Information
Drug ID	D0G9ZW
Former ID	DIB015603
Drug Name	Roquinimex
Synonyms	Linomide
Drug Type	Small molecular drug
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Discontinued in Phase 1	[544912]
Company	Pharmacia & Upjohn AB
Structure		Download 2D MOL 3D MOL
Formula	C18H16N2O3
Canonical SMILES	c1(c(=O)n(c2c(c1O)cccc2)C)C(=O)N(c1ccccc1)C
CAS Number	CAS 84088-42-6
PubChem Compound ID	54676478
Target and Pathway
Target(s)	Interleukin-2	Target Info	Modulator	[534129]
KEGG Pathway	Cytokine-cytokine receptor interaction
	PI3K-Akt signaling pathway
	Jak-STAT signaling pathway
	T cell receptor signaling pathway
	Intestinal immune network for IgA production
	Type I diabetes mellitus
	Chagas disease (American trypanosomiasis)
	Measles
	HTLV-I infection
	Autoimmune thyroid disease
	Inflammatory bowel disease (IBD)
	Allograft rejection
	Graft-versus-host disease
NetPath Pathway	IL-7 Signaling Pathway
	TCR Signaling Pathway
	TNFalpha Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Interleukin signaling pathway
Pathway Interaction Database	IL27-mediated signaling events
	IL12-mediated signaling events
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	SHP2 signaling
	Regulation of Telomerase
	Glucocorticoid receptor regulatory network
	IL2-mediated signaling events
	IL2 signaling events mediated by PI3K
	AP-1 transcription factor network
	IL23-mediated signaling events
	IL2 signaling events mediated by STAT5
	Calcium signaling in the CD4+ TCR pathway
	Downstream signaling in na&#xef
	IL12 signaling mediated by STAT4
Reactome	GPVI-mediated activation cascade
	G beta:gamma signalling through PI3Kgamma
	Interleukin-2 signaling
	RAF/MAP kinase cascade
	Interleukin receptor SHC signaling
WikiPathways	Cytokines and Inflammatory Response
	IL-2 Signaling Pathway
	Inflammatory Response Pathway
	Aryl Hydrocarbon Receptor Pathway
	Interleukin-2 signaling
	T-Cell Receptor and Co-stimulatory Signaling
	Spinal Cord Injury
	Corticotropin-releasing hormone
	Allograft Rejection
	Arylhydrocarbon receptor (AhR) signaling pathway
	Interleukin-3, 5 and GM-CSF signaling
	Folate Metabolism
	IL-5 Signaling Pathway
References
Ref 544912	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001478)
Ref 534129	The novel immunomodulator, Linomide, stimulates interleukin-2-induced human natural killer (NK) cell and PHA-stimulated T cell proliferation from normal donors. Leuk Res. 1996 Jan;20(1):57-63.

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