Drug Information

Drug General Information
Drug ID
D0G9YH
Former ID
DAP000046
Drug Name
Amsacrine
Synonyms
Acridinylanisidide; Amecrin; Amekrin; Amsacrina; Amsacrinum; Amsidine; Amsidyl; Amsine; Lamasine; MAMSA; NAMSA; Acridinyl Anisidide; SN 21429; SN11841; AMSA P-D; Acridinyl anisidide (TN); Amsacrina [INN-Spanish]; Amsacrinum [INN-Latin]; Amsidyl (TN); Cain's Acridine; M-AMSA; Meta-AMSA; Meta-Amsacrine; SN-11841; Amsacrine (USAN/INN); Amsacrine [USAN:BAN:INN]; M-AMSA (TN); N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide; N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide; N-[4-(9-Acridinylamino)-3-methoxy-phenyl]methanesulfonamide; N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide; N-[4-(acridin-9-ylmethyl)-3-methoxyphenyl]methanesulfonamide; N-(4-(Acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide; N-[4-(Acridin-9-ylamino)-3-(methyloxy)phenyl]methanesulfonamide; N-[4-(acridin-9-ylamino)-3-(methyloxy)phenyl]methanesulfonamide; 4'-(9-Acridinylamino)-3'-methoxymethanesulfonanilide; 4'-(9-Acridinylamino)methanesulfon-m-anisidide; 4'-(9-Acridinylamino)methanesulfon-meta-anisidide; 4'-(9-Acridinylamino)methanesulphon-m-anisidide
Drug Type
Small molecular drug
Indication Acute lymphoblastic leukemia [ICD9: 204.0, 556; ICD10:C91.0] Approved [537102]
Therapeutic Class
Anticancer Agents
Company
Travenol Laboratories Inc
Structure
Download
2D MOL

3D MOL
Formula
C21H19N3O3S
Canonical SMILES
COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C4<br />2
InChI
1S/C21H19N3O3S/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13,24H,1-2H3,(H,22,23)
InChIKey
XCPGHVQEEXUHNC-UHFFFAOYSA-N
CAS Number
CAS 51264-14-3
PubChem Compound ID
2179
PubChem Substance ID
4711, 137181, 597748, 5128698, 7849380, 7978704, 8137254, 8151483, 11110803, 11406388, 11447254, 11533500, 12013305, 14927834, 29221358, 46507539, 47440375, 48110554, 48415564, 48422855, 49815687, 49855467, 50110958, 53789073, 57321186, 78687979, 90341308, 99453443, 103166066, 103919715, 103925608, 104299838, 118043462, 121379628, 124633410, 124879323, 124879324, 125824264, 126659536, 126687025, 127318462, 127318463, 127318464, 127318465, 127318466, 127318467, 127318468, 127318469, 127318470, 127318471
ChEBI ID
ChEBI:2687
SuperDrug ATC ID
L01XX01
SuperDrug CAS ID
cas=051264143
Target and Pathway
Target(s) DNA topoisomerase II Target Info Inhibitor [535303]
References
Ref 537102Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle. J Assoc Res Otolaryngol. 2009 Jun;10(2):191-203. Epub 2009 Feb 25.
Ref 535303Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity. Anticancer Drug Des. 2000 Dec;15(6):413-21.

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