Drug General Information
Drug ID
D0G8UG
Former ID
DIB001922
Drug Name
Sulukast
Synonyms
LY-170680
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [540287], [544541]
Company
Eli Lilly & Co
Structure
Download
2D MOL

3D MOL

Formula
C25H36N4O3S
InChI
InChI=1S/C25H36N4O3S/c1-2-3-4-5-6-7-8-9-10-11-12-16-22(33-18-17-23(30)31)24(32)20-14-13-15-21(19-20)25-26-28-29-27-25/h10-16,19,22,24,32H,2-9,17-18H2,1H3,(H,30,31)(H,26,27,28,29)/b11-10-,16-12+/t22-,24+/m1/s1
InChIKey
YPHOSUPSOWQQCB-AFOLHBCXSA-N
CAS Number
CAS 98116-53-1
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Modulator
Leukotriene CysLT2 receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 540287(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3327).
Ref 544541Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000090)

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.