| Drug General Information |
| Drug ID |
D0G6XS
|
| Former ID |
DNC002441
|
| Drug Name |
Fucose
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C6H12O5
|
| Canonical SMILES |
CC1C(C(C(C(O1)O)O)O)O
|
| InChI |
1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2?,3-,4+,5?,6?/m1/s1
|
| InChIKey |
SHZGCJCMOBCMKK-DLABPRKASA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
Alpha-galactosidase A |
Target Info |
Inhibitor |
[1]
|
|---|
| Insulin-like growth factor I receptor |
Target Info |
Inhibitor |
[1]
|
| C1 esterase |
Target Info |
Inhibitor |
[1]
|
| Urokinase-type plasminogen activator |
Target Info |
Inhibitor |
[1]
|
| Leukocyte elastase |
Target Info |
Inhibitor |
[1]
|
| Acetylcholinesterase |
Target Info |
Inhibitor |
[1]
|
| Lactotransferrin |
Target Info |
Inhibitor |
[1]
|
| Coagulation factor VII |
Target Info |
Inhibitor |
[1]
|
| Cathepsin S |
Target Info |
Inhibitor |
[1]
|
| E-selectin |
Target Info |
Inhibitor |
[1]
|
| Cytotoxic T-lymphocyte protein 4 |
Target Info |
Inhibitor |
[1]
|
| Neuraminidase |
Target Info |
Inhibitor |
[1]
|
| P-selectin |
Target Info |
Inhibitor |
[1]
|
| Cholinesterase |
Target Info |
Inhibitor |
[1]
|
| Membrane-associated lectin type-C |
Target Info |
Inhibitor |
[1]
|
| High affinity immunoglobulin epsilon receptor |
Target Info |
Inhibitor |
[1]
|
| Lactase-phlorizin hydrolase |
Target Info |
Inhibitor |
[1]
|
| Dipeptidyl peptidase IV |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Galactose metabolism
|
|
Glycerolipid metabolism
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|
Sphingolipid metabolism
|
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Glycosphingolipid biosynthesis - globo series
|
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Lysosomehsa04014:Ras signaling pathway
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Rap1 signaling pathway
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HIF-1 signaling pathway
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FoxO signaling pathway
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Oocyte meiosis
|
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Endocytosis
|
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PI3K-Akt signaling pathway
|
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AMPK signaling pathway
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Focal adhesion
|
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Adherens junction
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Signaling pathways regulating pluripotency of stem cells
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Long-term depression
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Ovarian steroidogenesis
|
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Progesterone-mediated oocyte maturation
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Pathways in cancer
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Transcriptional misregulation in cancer
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Proteoglycans in cancer
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Glioma
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Prostate cancer
|
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Melanomahsa04610:Complement and coagulation cascades
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Pertussis
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Staphylococcus aureus infection
|
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Systemic lupus erythematosushsa04064:NF-kappa B signaling pathway
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Complement and coagulation cascades
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MicroRNAs in cancerhsa05202:Transcriptional misregulation in cancer
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Systemic lupus erythematosushsa00564:Glycerophospholipid metabolism
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Cholinergic synapsehsa04610:Complement and coagulation cascadeshsa04142:Lysosome
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Phagosome
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Antigen processing and presentation
|
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Tuberculosishsa04514:Cell adhesion molecules (CAMs)
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TNF signaling pathway
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African trypanosomiasis
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Malariahsa04514:Cell adhesion molecules (CAMs)
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T cell receptor signaling pathway
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Autoimmune thyroid disease
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Rheumatoid arthritisstm00511:Other glycan degradationhsa04514:Cell adhesion molecules (CAMs)
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Malaria
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Staphylococcus aureus infectionhsa04145:Phagosome
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Tuberculosis
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Measleshsa04071:Sphingolipid signaling pathway
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Fc epsilon RI signaling pathway
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Asthmahsa00052:Galactose metabolism
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Metabolic pathways
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Carbohydrate digestion and absorptionhsa04974:Protein digestion and absorption
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NetPath Pathway
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TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
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EGFR1 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
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TCR Signaling PathwayNetPath_22:Leptin Signaling Pathway
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IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
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IL4 Signaling Pathway
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TNFalpha Signaling Pathway
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ID Signaling PathwayNetPath_14:IL2 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
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Insulin/IGF pathway-protein kinase B signaling cascadeP00011:Blood coagulation
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Plasminogen activating cascade
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CCKR signaling map STP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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Muscarinic acetylcholine receptor 2 and 4 signaling pathway
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Nicotinic acetylcholine receptor signaling pathwayP00005:Angiogenesis
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Blood coagulationP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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Nicotinic acetylcholine receptor signaling pathway
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Pathway Interaction Database
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Plasma membrane estrogen receptor signaling
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SHP2 signaling
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IGF1 pathway
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Posttranslational regulation of adherens junction stability and dissassembly
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Integrins in angiogenesis
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Stabilization and expansion of the E-cadherin adherens junctionintegrin1_pathway:Beta1 integrin cell surface interactions
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E2F transcription factor network
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Beta3 integrin cell surface interactions
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Osteopontin-mediated events
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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amb2 Integrin signaling
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ATF-2 transcription factor network
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AP-1 transcription factor network
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Beta2 integrin cell surface interactions
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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Beta5 beta6 beta7 and beta8 integrin cell surface interactions
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FGF signaling pathwayupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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C-MYB transcription factor networkatf2_pathway:ATF-2 transcription factor networktxa2pathway:Thromboxane A2 receptor signaling
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Glucocorticoid receptor regulatory network
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ATF-2 transcription factor networknfat_tfpathway:Calcineurin-regulated NFAT-dependent transcription in lymphocytesil4_2pathway:IL4-mediated signaling events
|
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PathWhiz Pathway
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Sphingolipid Metabolism
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Galactose MetabolismPW000048:Phospholipid BiosynthesisPW000562:CoagulationPW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000153:Lactose Degradation
|
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Galactose Metabolism
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Reactome
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Glycosphingolipid metabolismR-HSA-2428928:IRS-related events triggered by IGF1R
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SHC-related events triggered by IGF1RR-HSA-75205:Dissolution of Fibrin ClotR-HSA-1442490:Collagen degradation
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Degradation of the extracellular matrix
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Activation of Matrix MetalloproteinasesR-HSA-1222556:ROS production in response to bacteria
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Amyloid formationR-HSA-1368108:BMAL1:CLOCK,NPAS2 activates circadian gene expression
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Extrinsic Pathway of Fibrin Clot Formation
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Gamma-carboxylation of protein precursors
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Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
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Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-1236977:Endosomal/Vacuolar pathway
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Trafficking and processing of endosomal TLR
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Assembly of collagen fibrils and other multimeric structures
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MHC class II antigen presentationR-HSA-202733:Cell surface interactions at the vascular wallR-HSA-389513:CTLA4 inhibitory signalingR-HSA-114608:Platelet degranulation
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Cell surface interactions at the vascular wallR-HSA-5621575:CD209 (DC-SIGN) signalingR-HSA-2454202:Fc epsilon receptor (FCERI) signaling
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Role of LAT2/NTAL/LAB on calcium mobilization
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FCERI mediated MAPK activation
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FCERI mediated Ca+2 mobilization
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FCERI mediated NF-kB activation
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WikiPathways
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Sphingolipid metabolismWP615:Senescence and Autophagy in Cancer
|
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Insulin Signaling
|
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Endochondral Ossification
|
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Focal Adhesion
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Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
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Apoptosis
|
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Signaling Pathways in Glioblastoma
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TSH signaling pathway
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MicroRNAs in cardiomyocyte hypertrophyWP558:Complement and Coagulation Cascades
|
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Complement Activation, Classical Pathway
|
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Human Complement System
|
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Complement cascadeWP710:DNA Damage Response (only ATM dependent)
|
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Senescence and Autophagy in Cancer
|
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Complement and Coagulation Cascades
|
|
Wnt Signaling Pathway
|
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Wnt Signaling Pathway and Pluripotency
|
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Blood Clotting Cascade
|
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Dissolution of Fibrin Clot
|
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Osteopontin SignalingWP2840:Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
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Degradation of collagenWP727:Monoamine Transport
|
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Biogenic Amine Synthesis
|
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Acetylcholine Synthesis
|
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Integrated Pancreatic Cancer PathwayWP2700:Latent infection of Homo sapiens with Mycobacterium tuberculosisWP558:Complement and Coagulation Cascades
|
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PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
|
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Formation of Fibrin Clot (Clotting Cascade)
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Circadian Clock
|
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Folate Metabolism
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Vitamin B12 Metabolism
|
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Selenium Micronutrient NetworkWP2796:Class I MHC mediated antigen processing & presentation
|
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Trafficking and processing of endosomal TLRWP2806:Human Complement System
|
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TNF alpha Signaling Pathway
|
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Cell surface interactions at the vascular wallWP2877:Vitamin D Receptor Pathway
|
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T-Cell Receptor and Co-stimulatory Signaling
|
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Allograft Rejection
|
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Costimulation by the CD28 familyWP2806:Human Complement System
|
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Spinal Cord Injury
|
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Cell surface interactions at the vascular wallWP229:Irinotecan PathwayWP2865:IL1 and megakaryotyces in obesity
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Fc epsilon receptor (FCERI) signalingWP1848:Metabolism of carbohydrates
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
