Drug Information

Drug General Information
Drug ID
D0G6XS
Former ID
DNC002441
Drug Name
Fucose
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL

3D MOL
Formula
C6H12O5
Canonical SMILES
CC1C(C(C(C(O1)O)O)O)O
InChI
1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2?,3-,4+,5?,6?/m1/s1
InChIKey
SHZGCJCMOBCMKK-DLABPRKASA-N
PubChem Compound ID
71315513
PubChem Substance ID
162260149, 188890872, 223725707, 238096084
Target and Pathway
Target(s) Alpha-galactosidase A Target Info Inhibitor [551393]
Insulin-like growth factor I receptor Target Info Inhibitor [551393]
C1 esterase Target Info Inhibitor [551393]
Urokinase-type plasminogen activator Target Info Inhibitor [551393]
Leukocyte elastase Target Info Inhibitor [551393]
Acetylcholinesterase Target Info Inhibitor [551393]
Lactotransferrin Target Info Inhibitor [551393]
Coagulation factor VII Target Info Inhibitor [551393]
Cathepsin S Target Info Inhibitor [551393]
E-selectin Target Info Inhibitor [551393]
Cytotoxic T-lymphocyte protein 4 Target Info Inhibitor [551393]
Neuraminidase Target Info Inhibitor [551393]
P-selectin Target Info Inhibitor [551393]
Cholinesterase Target Info Inhibitor [551393]
Membrane-associated lectin type-C Target Info Inhibitor [551393]
High affinity immunoglobulin epsilon receptor Target Info Inhibitor [551393]
Lactase-phlorizin hydrolase Target Info Inhibitor [551393]
Dipeptidyl peptidase IV Target Info Inhibitor [551393]
KEGG Pathway Galactose metabolism
Glycerolipid metabolism
Sphingolipid metabolism
Glycosphingolipid biosynthesis - globo series
Lysosomehsa04014:Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
Endocytosis
PI3K-Akt signaling pathway
AMPK signaling pathway
Focal adhesion
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanomahsa04610:Complement and coagulation cascades
Pertussis
Staphylococcus aureus infection
Systemic lupus erythematosushsa04064:NF-kappa B signaling pathway
Complement and coagulation cascades
MicroRNAs in cancerhsa05202:Transcriptional misregulation in cancer
Systemic lupus erythematosushsa00564:Glycerophospholipid metabolism
Cholinergic synapsehsa04610:Complement and coagulation cascadeshsa04142:Lysosome
Phagosome
Antigen processing and presentation
Tuberculosishsa04514:Cell adhesion molecules (CAMs)
TNF signaling pathway
African trypanosomiasis
Malariahsa04514:Cell adhesion molecules (CAMs)
T cell receptor signaling pathway
Autoimmune thyroid disease
Rheumatoid arthritisstm00511:Other glycan degradationhsa04514:Cell adhesion molecules (CAMs)
Malaria
Staphylococcus aureus infectionhsa04145:Phagosome
Tuberculosis
Measleshsa04071:Sphingolipid signaling pathway
Fc epsilon RI signaling pathway
Asthmahsa00052:Galactose metabolism
Metabolic pathways
Carbohydrate digestion and absorptionhsa04974:Protein digestion and absorption
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
EGFR1 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
TCR Signaling PathwayNetPath_22:Leptin Signaling Pathway
IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
ID Signaling PathwayNetPath_14:IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascadeP00011:Blood coagulation
Plasminogen activating cascade
CCKR signaling map STP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathwayP00005:Angiogenesis
Blood coagulationP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
SHP2 signaling
IGF1 pathway
Posttranslational regulation of adherens junction stability and dissassembly
Integrins in angiogenesis
Stabilization and expansion of the E-cadherin adherens junctionintegrin1_pathway:Beta1 integrin cell surface interactions
E2F transcription factor network
Beta3 integrin cell surface interactions
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
amb2 Integrin signaling
ATF-2 transcription factor network
AP-1 transcription factor network
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
FGF signaling pathwayupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor networkatf2_pathway:ATF-2 transcription factor networktxa2pathway:Thromboxane A2 receptor signaling
Glucocorticoid receptor regulatory network
ATF-2 transcription factor networknfat_tfpathway:Calcineurin-regulated NFAT-dependent transcription in lymphocytesil4_2pathway:IL4-mediated signaling events
PathWhiz Pathway Sphingolipid Metabolism
Galactose MetabolismPW000048:Phospholipid BiosynthesisPW000562:CoagulationPW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000153:Lactose Degradation
Galactose Metabolism
Reactome Glycosphingolipid metabolismR-HSA-2428928:IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1RR-HSA-75205:Dissolution of Fibrin ClotR-HSA-1442490:Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix MetalloproteinasesR-HSA-1222556:ROS production in response to bacteria
Amyloid formationR-HSA-1368108:BMAL1:CLOCK,NPAS2 activates circadian gene expression
Extrinsic Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-1236977:Endosomal/Vacuolar pathway
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-202733:Cell surface interactions at the vascular wallR-HSA-389513:CTLA4 inhibitory signalingR-HSA-114608:Platelet degranulation
Cell surface interactions at the vascular wallR-HSA-5621575:CD209 (DC-SIGN) signalingR-HSA-2454202:Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
WikiPathways Sphingolipid metabolismWP615:Senescence and Autophagy in Cancer
Insulin Signaling
Endochondral Ossification
Focal Adhesion
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Apoptosis
Signaling Pathways in Glioblastoma
TSH signaling pathway
MicroRNAs in cardiomyocyte hypertrophyWP558:Complement and Coagulation Cascades
Complement Activation, Classical Pathway
Human Complement System
Complement cascadeWP710:DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Complement and Coagulation Cascades
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Blood Clotting Cascade
Dissolution of Fibrin Clot
Osteopontin SignalingWP2840:Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Degradation of collagenWP727:Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer PathwayWP2700:Latent infection of Homo sapiens with Mycobacterium tuberculosisWP558:Complement and Coagulation Cascades
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Formation of Fibrin Clot (Clotting Cascade)
Circadian Clock
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient NetworkWP2796:Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLRWP2806:Human Complement System
TNF alpha Signaling Pathway
Cell surface interactions at the vascular wallWP2877:Vitamin D Receptor Pathway
T-Cell Receptor and Co-stimulatory Signaling
Allograft Rejection
Costimulation by the CD28 familyWP2806:Human Complement System
Spinal Cord Injury
Cell surface interactions at the vascular wallWP229:Irinotecan PathwayWP2865:IL1 and megakaryotyces in obesity
Fc epsilon receptor (FCERI) signalingWP1848:Metabolism of carbohydrates
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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