Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0G6EO
|
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| Former ID |
DIB001842
|
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| Drug Name |
Hemoximer
|
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| Synonyms |
PHP-CT; PHP-HT; PHP-OC; Pyridoxalated hemoglobin polyoxyethylene-CT; Pyridoxalated hemoglobin polyoxyethylene-HT; Pyridoxalated hemoglobin polyoxyethylene-OC; VTR-PHP
|
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| Indication | Hypotension [ICD9: 458, 796.3; ICD10:I95] | Discontinued in Phase 3 | [1] | ||
| Company |
Ajinomoto Co Inc
|
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| Target and Pathway | |||||
| Target(s) | Hemoglobin | Target Info | Antagonist | [2] | |
| KEGG Pathway | African trypanosomiasis | ||||
| Malaria | |||||
| Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
| Erythrocytes take up oxygen and release carbon dioxide | |||||
| Scavenging of heme from plasma | |||||
| WikiPathways | Binding and Uptake of Ligands by Scavenger Receptors | ||||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | |||||
| Factors involved in megakaryocyte development and platelet production | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008774) | ||||
| REF 2 | Effect of NaBH4 Concentration and Reaction Time on Physical Properties of Glutaraldehyde-Polymerized Hemoglobin. Biotechnology Progress. 05/2004; 20(3):946-52. | ||||
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