Drug Information

Drug General Information
Drug ID
D0G5MR
Former ID
DNC001105
Drug Name
PD184352
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535353]
Structure
Download
2D MOL

3D MOL
Formula
C17H14ClF2IN2O2
Canonical SMILES
C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
InChI
1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
InChIKey
GFMMXOIFOQCCGU-UHFFFAOYSA-N
PubChem Compound ID
6918454
PubChem Substance ID
12015277, 14785570, 17194900, 43529824, 50219944, 53790065, 57371938, 68529932, 91615541, 99432369, 103320975, 104023279, 114787998, 124756939, 125163746, 125682631, 126666989, 126731600, 127946482, 131465109, 134348393, 134964403, 135252709, 135685254, 135685255, 135685274, 135686122, 135686123, 135686144, 135686145, 135697602, 135727460, 136920309, 137051942, 141704189, 144206914, 152258802, 152344236, 160647653, 162011728, 162037388, 162202579, 162814558, 164043524, 164764084, 170466835, 172914355, 174006413, 174560970, 176239066
Target and Pathway
Target(s) MEKK-1 kinase Target Info Inhibitor [535353]
Mitogen-activated protein kinase kinase kinase 2 Target Info Inhibitor [535353]
KEGG Pathway MAPK signaling pathway
Ubiquitin mediated proteolysis
RIG-I-like receptor signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Hepatitis B
HTLV-I infectionhsa04010:MAPK signaling pathway
Gap junction
NetPath Pathway IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Angiogenesis
Apoptosis signaling pathway
T cell activation
Ras PathwayP00010:B cell activation
EGF receptor signaling pathway
FGF signaling pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
p38 MAPK signaling pathway
CD40/CD40L signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Osteopontin-mediated events
TRAIL signaling pathway
CDC42 signaling events
FAS (CD95) signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
TNF receptor signaling pathway
Ceramide signaling pathway
IFN-gamma pathway
ErbB1 downstream signaling
JNK signaling in the CD4+ TCR pathway
Caspase Cascade in Apoptosis
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
RAC1 signaling pathwayerbb1_downstream_pathway:ErbB1 downstream signaling
Trk receptor signaling mediated by the MAPK pathway
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome MyD88:Mal cascade initiated on plasma membrane
FCERI mediated MAPK activation
TRAF6 mediated NF-kB activation
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 cascade initiated on plasma membrane
WikiPathways Serotonin HTR1 Group and FOS Pathway
DNA Damage Response (only ATM dependent)
Interferon type I signaling pathways
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Cascade
p38 MAPK Signaling Pathway
Apoptosis Modulation by HSP70
MAPK Signaling Pathway
FAS pathway and Stress induction of HSP regulation
MyD88 cascade initiated on plasma membrane
Cardiac Hypertrophic Response
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
Fc epsilon receptor (FCERI) signaling
Structural Pathway of Interleukin 1 (IL-1)
Polycystic Kidney Disease Pathway
Apoptosis
PDGF Pathway
BDNF signaling pathway
TNF alpha Signaling Pathway
IL-1 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysWP481:Insulin Signaling
References
Ref 535353Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.
Ref 535353Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.

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