Drug Information

Drug General Information
Drug ID
D0G5GJ
Former ID
DNC001191
Drug Name
R-68151
Drug Type
Small molecular drug
Indication Psoriasis [ICD9: 696; ICD10:L40] Discontinued in Phase 2 [545537]
Structure
Download
2D MOL

3D MOL
Formula
C23H28N4O2S
Canonical SMILES
CCN1C(=S)N(C(=O)C1(C)C)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C<br />=C4)O
InChI
1S/C23H28N4O2S/c1-4-26-22(30)27(21(29)23(26,2)3)19-7-5-17(6-8-19)24-13-15-25(16-14-24)18-9-11-20(28)12-10-18/h5-12,28H,4,13-16H2,1-3H3
InChIKey
AHWDHLCCXRVAIC-UHFFFAOYSA-N
CAS Number
CAS 138331-04-1
PubChem Compound ID
132150
PubChem Substance ID
10243053, 14831880, 29310369, 76984529, 103289644, 103920111, 104376801, 126437330, 127408986, 134340204, 134340415, 135087000, 137828730, 141541260, 238689243
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [535027], [538009]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 545537Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003630)
Ref 535027Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45.
Ref 538009Topical R-85355, a potent and selective 5-lipoxygenase inhibitor, fails to improve psoriasis. Skin Pharmacol. 1996;9(5):307-11.

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