Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0G4OT
|
||||
| Former ID |
DCL001039
|
||||
| Drug Name |
XL784
|
||||
| Indication | Diabetic nephropathy [ICD9: 250.4; ICD10:E11.21] | Discontinued in Phase 2 | [536836] | ||
| Company |
Exelixis
|
||||
| Target and Pathway | |||||
| Target(s) | Interstitial collagenase | Target Info | Inhibitor | [536836] | |
| PANTHER Pathway | Alzheimer disease-presenilin pathway | ||||
| Plasminogen activating cascade | |||||
| WikiPathways | TGF beta Signaling Pathway | ||||
| Bladder Cancer | |||||
| Activation of Matrix Metalloproteinases | |||||
| Degradation of collagen | |||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | |||||
| Oncostatin M Signaling Pathway | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Integrated Cancer pathway | |||||
| Cell surface interactions at the vascular wall | |||||
| Matrix Metalloproteinases | |||||
| References | |||||
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