| Drug General Information |
| Drug ID |
D0G3MH
|
| Former ID |
DIB014392
|
| Drug Name |
PNU-96391A
|
| Synonyms |
DS 121; (-)-DS-121; (-)-OSU-6162
|
| Drug Type |
Small molecular drug
|
| Indication |
Substance dependence [ICD10:F10-F19]
|
Terminated |
[1]
|
|---|
| Company |
University of Gothenburg
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H23NO2S
|
| Canonical SMILES |
S(=O)(=O)(c1cc([C@H]2CN(CCC2)CCC)ccc1)C
|
| CAS Number |
CAS 150336-90-6
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
D(3) dopamine receptor |
Target Info |
Modulator |
[1]
|
|---|
| D(2) dopamine receptor |
Target Info |
Modulator |
[1]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Dopaminergic synapsehsa04015:Rap1 signaling pathway
|
|
cAMP signaling pathway
|
|
Gap junction
|
|
Dopaminergic synapse
|
|
Parkinson's disease
|
|
Cocaine addiction
|
|
Alcoholism
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Dopamine receptor mediated signaling pathway
|
|
Nicotine pharmacodynamics pathway
|
|
Reactome
|
Dopamine receptors
|
|
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
Nicotine Activity on Dopaminergic Neurons
|
|
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
|
|
Genes and (Common) Pathways Underlying Drug Addiction
|
| References |
| REF 1 | The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects. Neuropsychopharmacology. 2015 Jan;40(2):472-9. |
|---|
