Drug General Information
Drug ID
D0G2GR
Former ID
DIB001638
Drug Name
OP-2507
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 2 [545937]
Company
Ono Pharmaceutical Co Ltd
Structure
Download
2D MOL

3D MOL

Formula
C25H41NO4
Canonical SMILES
[C@@H]12N=C(C[C@@H]1[C@@H](/C=C/[C@H]([C@H]1CC[C@H](CC1<br />)CCC)O)[C@@H](C2)O)CCCCC(=O)OC
CAS Number
CAS 101758-79-6
PubChem Compound ID
Target and Pathway
Target(s) Prostacyclin receptor Target Info Modulator [531344]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 545937Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005417)
Ref 531344Effect of a prostaglandin I(2) analog on the expression of thrombomodulin in liver and spleen endothelial cells after an extensive hepatectomy. Surg Today. 2011 Feb;41(2):230-6.

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