Drug Information

Drug General Information
Drug ID
D0G1TY
Former ID
DCL000020
Drug Name
CPG 52364
Drug Type
Small molecular drug
Indication Systemic lupus erythematosus [ICD9: 710; ICD10:M32] Phase 1 [532501]
Company
Coley Pharma.
Structure
Download
2D MOL

3D MOL
Formula
C24H32N6O2
Canonical SMILES
CN(C)CCNC1=NC(=NC2=CC(=C(C=C21)OC)OC)N3CCN(CC3)C4=CC=CC<br />=C4
InChI
1S/C24H32N6O2/c1-28(2)11-10-25-23-19-16-21(31-3)22(32-4)17-20(19)26-24(27-23)30-14-12-29(13-15-30)18-8-6-5-7-9-18/h5-9,16-17H,10-15H2,1-4H3,(H,25,26,27)
InChIKey
NRDOWTUUBQCUMC-UHFFFAOYSA-N
PubChem Compound ID
11774935
ChEBI ID
ChEBI:51098
Target and Pathway
Target(s) Toll-like receptor 7 Target Info Antagonist [551089]
Toll-like receptor 9 Target Info Antagonist [551089]
Toll-like receptor 8 Target Info Antagonist [551089]
KEGG Pathway Toll-like receptor signaling pathway
Measles
Influenza Ahsa04620:Toll-like receptor signaling pathway
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Tuberculosis
Herpes simplex infectionhsa04620:Toll-like receptor signaling pathway
NetPath Pathway TCR Signaling PathwayNetPath_12:BCR Signaling PathwayNetPath_22:Leptin Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathwayP00054:Toll receptor signaling pathwayP00054:Toll receptor signaling pathway
Reactome Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosomeR-HSA-109704:PI3K Cascade
MyD88 dependent cascade initiated on endosomeR-HSA-1679131:Trafficking and processing of endosomal TLR
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Regulation of toll-like receptor signaling pathway
References
Ref 532501Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys. Nat Rev Rheumatol. 2014 Jan;10(1):23-34.
Ref 551089Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus. Lupus Foundation of America, Inc. 2007.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.