Drug Information
Drug General Information | |||||
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Drug ID |
D0G0FJ
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Former ID |
DNC004676
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Drug Name |
2-hydrazinylbenzenesulfonamide
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Synonyms |
2-Hydrazino-benzenesulfonamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529948] | ||
Structure |
Download2D MOL |
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Formula |
C6H9N3O2S
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Canonical SMILES |
C1=CC=C(C(=C1)NN)S(=O)(=O)N
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InChI |
1S/C6H9N3O2S/c7-9-5-3-1-2-4-6(5)12(8,10)11/h1-4,9H,7H2,(H2,8,10,11)
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InChIKey |
CTEZEDIMFASQNI-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Carbonic anhydrase VI | Target Info | Inhibitor | [529948] | |
Carbonic anhydrase IX | Target Info | Inhibitor | [529948] | ||
Carbonic anhydrase II | Target Info | Inhibitor | [537461] | ||
Carbonic anhydrase XII | Target Info | Inhibitor | [527407] | ||
Carbonic anhydrase | Target Info | Inhibitor | [529948] | ||
Pathway Interaction Database | HIF-1-alpha transcription factor network | ||||
Reactome | Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor | ||||
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
Erythrocytes take up oxygen and release carbon dioxide | |||||
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide | |||||
WikiPathways | Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway | ||||
Reversible Hydration of Carbon Dioxide | |||||
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide | |||||
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
miR-targeted genes in muscle cell - TarBase | |||||
miR-targeted genes in leukocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBase | |||||
References | |||||
Ref 527407 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?. | ||||
Ref 529948 | J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. | ||||
Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. |
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