Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0FO2K
|
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| Former ID |
DNC003252
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| Drug Name |
N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [551374] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C20H15N3O3
|
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| Canonical SMILES |
C1=CC=C(C=C1)C2=C(OC3=NC=NC(=C23)NCC(=O)O)C4=CC=CC=C4
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| InChI |
1S/C20H15N3O3/c24-15(25)11-21-19-17-16(13-7-3-1-4-8-13)18(14-9-5-2-6-10-14)26-20(17)23-12-22-19/h1-10,12H,11H2,(H,24,25)(H,21,22,23)
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| InChIKey |
VXTCEUDVOCLEJG-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3619204, 4273590, 6436001, 7886989, 8247092, 16341861, 45837560, 46393926, 46515126, 47289836, 47735008, 49947491, 51924040, 84910327, 85834567, 89168588, 99444124, 103459685, 103855282, 110055255, 137185243, 138092318, 138649074, 152096629, 160968723, 163667323, 164850636, 166199081, 179046775, 186019991, 232440213
|
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| Target and Pathway | |||||
| Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Inhibitor | [551374] | |
| Pathway Interaction Database | Fanconi anemia pathway | ||||
| p73 transcription factor network | |||||
| ATR signaling pathway | |||||
| Circadian rhythm pathway | |||||
| p53 pathway | |||||
| Reactome | Activation of ATR in response to replication stress | ||||
| Processing of DNA double-strand break ends | |||||
| Presynaptic phase of homologous DNA pairing and strand exchange | |||||
| G2/M DNA damage checkpoint | |||||
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |||||
| References | |||||
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