Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0F9BX
|
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| Former ID |
DIB003264
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| Drug Name |
GW-660511
|
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| Synonyms |
GW-660511X; Z-13752A
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| Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Terminated | [1] | ||
| Company |
Zambon Co SpA
|
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
C(=O)(N[C@H](C(=O)O)Cc1ccc(c2nccs2)cc1)[C@H](Cc1ccccc1)<br />CS
|
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| CAS Number |
CAS 193420-09-6
|
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| Target and Pathway | |||||
| Target(s) | Neutral endopeptidase | Target Info | Modulator | [1] | |
| Angiotensin-converting enzyme | Target Info | Modulator | [1] | ||
| KEGG Pathway | Renin-angiotensin system | ||||
| Hematopoietic cell lineage | |||||
| Protein digestion and absorption | |||||
| Alzheimer's diseasehsa04614:Renin-angiotensin system | |||||
| Chagas disease (American trypanosomiasis) | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| PathWhiz Pathway | Angiotensin Metabolism | ||||
| Reactome | Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins | ||||
| WikiPathways | Metabolism of Angiotensinogen to Angiotensins | ||||
| Primary Focal Segmental Glomerulosclerosis FSGS | |||||
| Alzheimers DiseaseWP554:ACE Inhibitor Pathway | |||||
| References | |||||
| REF 1 | The effects of Z13752A, a combined ACE/NEP inhibitor, on responses to coronary artery occlusion; a primary protective role for bradykinin. Br J Pharmacol. 2000 Feb;129(4):671-80. | ||||
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