Drug General Information
Drug ID	D0F9BX
Former ID	DIB003264
Drug Name	GW-660511
Synonyms	GW-660511X; Z-13752A
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Terminated	[525698]
Company	Zambon Co SpA
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(N[C@H](C(=O)O)Cc1ccc(c2nccs2)cc1)[C@H](Cc1ccccc1)<br />CS
CAS Number	CAS 193420-09-6
Target and Pathway
Target(s)	Neutral endopeptidase	Target Info	Modulator	[525698]
	Angiotensin-converting enzyme	Target Info	Modulator	[525698]
KEGG Pathway	Renin-angiotensin system
	Hematopoietic cell lineage
	Protein digestion and absorption
	Alzheimer's diseasehsa04614:Renin-angiotensin system
	Chagas disease (American trypanosomiasis)
	Hypertrophic cardiomyopathy (HCM)
NetPath Pathway	EGFR1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Angiotensin Metabolism
Reactome	Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins
WikiPathways	Metabolism of Angiotensinogen to Angiotensins
	Primary Focal Segmental Glomerulosclerosis FSGS
	Alzheimers DiseaseWP554:ACE Inhibitor Pathway
References
Ref 525698	The effects of Z13752A, a combined ACE/NEP inhibitor, on responses to coronary artery occlusion; a primary protective role for bradykinin. Br J Pharmacol. 2000 Feb;129(4):671-80.
Ref 525698	The effects of Z13752A, a combined ACE/NEP inhibitor, on responses to coronary artery occlusion; a primary protective role for bradykinin. Br J Pharmacol. 2000 Feb;129(4):671-80.

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