Drug Information

Drug General Information
Drug ID
D0F8CC
Former ID
DIB019087
Drug Name
CD666
Synonyms
CD-666; CD 666
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539719]
Structure
Download
2D MOL
Formula
C24H28O3
InChI
InChI=1S/C24H28O3/c1-23(2)13-14-24(3,4)20-15-18(10-11-19(20)23)21(25)12-7-16-5-8-17(9-6-16)22(26)27/h5-12,15,21,25H,13-14H2,1-4H3,(H,26,27)/b12-7+
InChIKey
QCSYBKHFYYISTQ-KPKJPENVSA-N
PubChem Compound ID
10090192
PubChem Substance ID
15077289, 24442713, 39150074, 53801005, 74820048, 85240514, 103311553, 142496700, 172080051, 237626751
Target and Pathway
Target(s) Retinoic acid receptor gamma Target Info Agonist [526744]
Retinoic acid receptor beta Target Info Agonist [526744]
Retinoic acid receptor alpha Target Info Agonist [526744]
KEGG Pathway Pathways in cancer
Small cell lung cancer
Non-small cell lung cancerhsa05200:Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Pathway Interaction Database Retinoic acid receptors-mediated signaling
Reactome Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Mesodermal Commitment Pathway
Endoderm Differentiation
Nuclear ReceptorsWP716:Vitamin A and Carotenoid Metabolism
Integrated Pancreatic Cancer Pathway
Adipogenesis
Nuclear Receptors
References
Ref 539719(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2652).
Ref 526744Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83.

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