TTD | Drug: D0F6CT

Drug General Information
Drug ID	D0F6CT
Former ID	DCL000119
Drug Name	GI 181771
Drug Type	Small molecular drug
Indication	Obesity [ICD9: 278; ICD10:E66]		Discontinued in Phase 2	[547133]
Company	GlaxoSmithKline
Structure		Download 2D MOL 3D MOL
Formula	C34H31N5O6
Canonical SMILES	CC(C)N(C1=CC=CC=C1)C(=O)CN2C3=CC=CC=C3N(C(=O)C(C2=O)NC(<br />=O)NC4=CC=CC(=C4)C(=O)O)C5=CC=CC=C5
InChI	1S/C34H31N5O6/c1-22(2)38(25-14-5-3-6-15-25)29(40)21-37-27-18-9-10-19-28(27)39(26-16-7-4-8-17-26)32(42)30(31(37)41)36-34(45)35-24-13-11-12-23(20-24)33(43)44/h3-20,22,30H,21H2,1-2H3,(H,43,44)(H2,35,36,45)/t30-/m0/s1
InChIKey	CABBMMXFOOZVMS-PMERELPUSA-N
PubChem Compound ID	51353551
PubChem Substance ID	121272446, 123087925, 123108293, 134338804, 163642200, 198984882
Target and Pathway
Target(s)	Cholecystokinin receptor type A	Target Info	Agonist	[535784]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Insulin secretion
	Pancreatic secretion
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 547133	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013294)
Ref 535784	Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jul-Aug;25(6):483-506.

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Drug Information