Drug Information
Drug General Information | |||||
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Drug ID |
D0F3JT
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Former ID |
DAP000287
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Drug Name |
Mecasermin
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Synonyms |
Increlex (TN)
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Therapeutic Class |
Immunomodulatory Agents
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Formula |
C331H518N94O101S7
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CAS Number |
CAS 68562-41-4
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SuperDrug ATC ID |
H01AC03
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Target and Pathway | |||||
Target(s) | Insulin-like growth factor I receptor | Target Info | Inhibitor | [535735], [535760], [535800], [536311] | |
KEGG Pathway | Ras signaling pathway | ||||
Rap1 signaling pathway | |||||
HIF-1 signaling pathway | |||||
FoxO signaling pathway | |||||
Oocyte meiosis | |||||
Endocytosis | |||||
PI3K-Akt signaling pathway | |||||
AMPK signaling pathway | |||||
Focal adhesion | |||||
Adherens junction | |||||
Signaling pathways regulating pluripotency of stem cells | |||||
Long-term depression | |||||
Ovarian steroidogenesis | |||||
Progesterone-mediated oocyte maturation | |||||
Pathways in cancer | |||||
Transcriptional misregulation in cancer | |||||
Proteoglycans in cancer | |||||
Glioma | |||||
Prostate cancer | |||||
Melanoma | |||||
References | |||||
Ref 535735 | One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Arthritis Rheum. 2003 May;48(5):1302-14. | ||||
Ref 535760 | IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 2003 Aug;443(2):139-45. Epub 2003 Jul 5. | ||||
Ref 535800 | Insulin-like growth factor I receptor gene structure. J Biol Chem. 1992 May 25;267(15):10759-63. | ||||
Ref 536311 | Analysis of the human type I insulin-like growth factor receptor promoter region. Biochem Biophys Res Commun. 1991 Jun 28;177(3):1113-20. |
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