Drug General Information
Drug ID
D0F1VQ
Former ID
DIB003966
Drug Name
ZIFROSILONE
Synonyms
MDL-73745; Zifrosilone < Rec INN; 2,2,2-Trifluoro-1-[3-(trimethylsilyl)phenyl]ethanone
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Discontinued in Phase 2 [545006]
Structure
Download
2D MOL

3D MOL

Formula
C11H13F3OSi
Canonical SMILES
C[Si](C)(C)C1=CC=CC(=C1)C(=O)C(F)(F)F
InChI
1S/C11H13F3OSi/c1-16(2,3)9-6-4-5-8(7-9)10(15)11(12,13)14/h4-7H,1-3H3
InChIKey
GAPOASFZXBWUGS-UHFFFAOYSA-N
CAS Number
CAS 132236-18-1
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [533665], [551871]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 545006Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001855)
Ref 533665Acetylcholinesterase inhibition by zifrosilone: pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 1995 Jul;58(1):54-61.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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