| Drug General Information |
| Drug ID |
D0F1MU
|
| Former ID |
DIB011360
|
| Drug Name |
EML-336
|
| Synonyms |
CRE-16336; EML-16336; ONO-5816
|
| Indication |
Type 2 diabetes [ICD9: 250; ICD10:E11]
|
Discontinued in Phase 2 |
[1]
|
|---|
| Company |
Merck Sante SA
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
N1C(=O)SC(C1=O)CCOc1ccc(C#N)cc1
|
| CAS Number |
CAS 200631-89-6
|
| Target and Pathway |
| Target(s) |
Insulin receptor |
Target Info |
Modulator |
[2]
|
|---|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
HIF-1 signaling pathway
|
|
FoxO signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
AMPK signaling pathway
|
|
Adherens junction
|
|
Insulin signaling pathway
|
|
Ovarian steroidogenesis
|
|
Type II diabetes mellitus
|
|
Non-alcoholic fatty liver disease (NAFLD)
|
|
Aldosterone-regulated sodium reabsorption
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
|
PANTHER Pathway
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
|
PI3 kinase pathway
|
|
Pathway Interaction Database
|
Insulin Pathway
|
|
Signaling events mediated by PTP1B
|
|
Signaling events mediated by TCPTP
|
|
Insulin-mediated glucose transport
|
|
PathWhiz Pathway
|
Insulin Signalling
|
|
Leucine Stimulation on Insulin Signaling
|
|
Reactome
|
IRS activation
|
|
Signal attenuation
|
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Insulin receptor signalling cascade
|
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Insulin receptor recycling
|
|
WikiPathways
|
DNA Damage Response (only ATM dependent)
|
|
Insulin Signaling
|
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Nanoparticle triggered autophagic cell death
|
|
AGE/RAGE pathway
|
|
Signaling by Insulin receptor
|
|
Folate Metabolism
|
|
Type II diabetes mellitus
|
|
Vitamin B12 Metabolism
|
|
Selenium Micronutrient Network
|
|
AMPK Signaling
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016521) |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). |
|---|
