Drug General Information
Drug ID	D0EK1C
Former ID	DIB015750
Drug Name	PHE-377
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Phase 1	[549036]
Company	PharmEste SRL
Structure		Download 2D MOL 3D MOL
Formula	C16H27ClN2O
Canonical SMILES	CC1=C(C(=CC=C1)C)NC(=O)C[NH+](C(C)C)C(C)C.[Cl-]
InChIKey	OJTPHJHZGWBMET-UHFFFAOYSA-N
PubChem Compound ID	53956
PubChem Substance ID	8183399, 34717993, 49863876, 51825452, 104303603, 117370867, 126420067, 135011919
Target and Pathway
Target(s)	Vanilloid receptor 1	Target Info	Antagonist	[551503]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
NetPath Pathway	IL2 Signaling Pathway
Pathway Interaction Database	Trk receptor signaling mediated by the MAPK pathway
	Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome	TRP channels
References
Ref 549036	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031648)
Ref 551503	Clinical pipeline report, company report or official report of Pharmeste.

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