Drug General Information
Drug ID	D0E9PK
Former ID	DNC004144
Drug Name	MOXONIDINE
Drug Type	Small molecular drug
Indication	Alcohol use disorders [ICD9: 303; ICD10:F10.2]		Approved	[526626]
Structure		Download 2D MOL 3D MOL
Formula	C9H15Cl2N5O2
Canonical SMILES	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC
InChI	1S/C9H12ClN5O/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9/h3-4H2,1-2H3,(H2,11,12,15)
InChIKey	WPNJAUFVNXKLIM-UHFFFAOYSA-N
CAS Number	CAS 75438-57-2
PubChem Compound ID	6917782
SuperDrug ATC ID	C02AC05
Target and Pathway
Target(s)	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[534128]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[534128]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[534128]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	GPCR downstream signaling
References
Ref 526626	The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. J Pharmacol Exp Ther.2003 Aug;306(2):646-57. Epub 2003 May 19.
Ref 534128	J Med Chem. 1996 Mar 15;39(6):1193-5.Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent.

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