Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0E8SE
|
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| Former ID |
DIB013025
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| Drug Name |
443C81
|
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| Synonyms |
BW 443C; BW-443C81
|
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| Indication | Asthma [ICD10:J45] | Terminated | [1] | ||
| Company |
Burroughs Wellcome Inc
|
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
N1(C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(<br />cc2)O)N)CCCNC(=N)N)Cc2ccc([N+](=O)[O-])cc2)[C@H](C(=O)N<br />)CCC1
|
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| Target and Pathway | |||||
| Target(s) | Mu-type opioid receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Estrogen signaling pathway | |||||
| Morphine addiction | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Enkephalin release | |||||
| Pathway Interaction Database | IL4-mediated signaling events | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | TCR Signaling Pathway | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Peptide GPCRs | |||||
| Opioid Signalling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000227) | ||||
| REF 2 | Inhibition of cholinergic neurotransmission in human airways by opioids. J Appl Physiol (1985). 1992 Mar;72(3):1096-100. | ||||
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