Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0E8KS
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| Former ID |
DNC001279
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| Drug Name |
SB 203186
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Terminated | [1], [2] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C16H20N2O2
|
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| InChI |
InChI=1S/C16H20N2O2/c19-16(20-11-10-18-8-4-1-5-9-18)14-12-17-15-7-3-2-6-13(14)15/h2-3,6-7,12,17H,1,4-5,8-11H2
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| InChIKey |
YGKPIROTKVQCCU-UHFFFAOYSA-N
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| CAS Number |
CAS 135938-17-9
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
4310608, 9251882, 11111770, 11113704, 15221946, 26751893, 34646190, 48018901, 48169370, 48393930, 50104570, 57356138, 77935497, 85213147, 85787316, 111881535, 123084781, 124749640, 124881385, 124881386, 124881387, 129792181, 134340485, 135650982, 136351878, 137031077, 138956298, 225044358, 227291137
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 4 receptor | Target Info | Antagonist | [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT4 type receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 255). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002177) | ||||
| REF 3 | 5-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist. J Vet Pharmacol Ther. 2002 Feb;25(1):49-58. | ||||
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