| Drug General Information |
| Drug ID |
D0E8HU
|
| Former ID |
DNC012840
|
| Drug Name |
3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H12FN
|
| Canonical SMILES |
C1C(NCC2=CC=CC=C21)CF
|
| InChI |
1S/C10H12FN/c11-6-10-5-8-3-1-2-4-9(8)7-12-10/h1-4,10,12H,5-7H2
|
| InChIKey |
SLBKHMRNZGCZIO-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Alpha-2B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Alpha-2A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-2C adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
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|
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interaction
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PANTHER Pathway
|
Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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|
Reactome
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Adrenoceptors
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Adrenaline signalling through Alpha-2 adrenergic receptor
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G alpha (i) signalling events
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G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
|
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Adrenaline,noradrenaline inhibits insulin secretion
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G alpha (z) signalling events
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Surfactant metabolismR-HSA-390696:Adrenoceptors
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Surfactant metabolism
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WikiPathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
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Integration of energy metabolism
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GPCR downstream signaling
|
| References |
| REF 1 | J Med Chem. 2005 Jan 13;48(1):134-40.3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity. |
|---|
