Drug General Information
Drug ID	D0E6SB
Former ID	DIB013438
Drug Name	HQK-1001
Synonyms	Sodium ST-20; Hematological disease therapeutic (oral), HemaQuest
Drug Type	Small molecular drug
Indication	Beta thalassemia [ICD10:D56.1]		Phase 2	[525404]
Company	Hemaquest pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C6H11NaO2
Canonical SMILES	CCC(C)(C)C(=O)[O-].[Na+]
InChI	1S/C6H12O2.Na/c1-4-6(2,3)5(7)8;/h4H2,1-3H3,(H,7,8);/q;+1/p-1
InChIKey	OOPXYEYPPHJHSE-UHFFFAOYSA-M
PubChem Compound ID	53247304
PubChem Substance ID	124363624, 124963053, 142349127, 172648310, 176270357, 198954263, 227412518
Target and Pathway
Target(s)	Hemoglobin	Target Info	Inducer	[532549]
KEGG Pathway	African trypanosomiasis
	Malaria
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Scavenging of heme from plasma
WikiPathways	Binding and Uptake of Ligands by Scavenger Receptors
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
	Factors involved in megakaryocyte development and platelet production
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 525404	A phase 2 trial of HQK-1001 in HbE-beta thalassemia demonstrates HbF induction and reduced anemia. Blood. 2014 Mar 20;123(12):1956-7.
Ref 532549	A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in beta-thalassaemia intermedia. Br J Haematol. 2014 Feb;164(3):456-8.

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