Drug Information

Drug General Information
Drug ID
D0E5NY
Former ID
DIB014295
Drug Name
AZD-2423
Synonyms
CCR2b antagonist (pain, COPD), AstraZeneca
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 2 [523197], [542770]
Company
AstraZeneca plc
Structure
Download
2D MOL
Formula
C20H29ClFN5O2
InChI
InChI=1S/C19H27ClFN5O2/c1-13(2)26-6-5-22-17(12-26)18(27)24-7-9-25(10-8-24)19(28)23-14-3-4-15(20)16(21)11-14/h3-4,11,13,17,22H,5-10,12H2,1-2H3,(H,23,28)/t17-/m1/s1
InChIKey
WERHXSXPOAOBJV-QGZVFWFLSA-N
PubChem Compound ID
46213922
PubChem Substance ID
96068292, 120478630, 140872550, 224398574, 228598750, 249338214
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Antagonist [550850]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 523197ClinicalTrials.gov (NCT01215279) AZD2423 Safety and Tolerability Study in Patients With Moderate and Severe Chronic Obstructive Pulmonary Disease(COPD). U.S. National Institutes of Health.
Ref 542770(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7825).
Ref 550850CA patent application no. 841416, Method of selecting therapeutic indications.

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