| Drug General Information |
| Drug ID |
D0E4JL
|
| Former ID |
DNC001233
|
| Drug Name |
Rotigitine
|
| Drug Type |
Small molecular drug
|
| Indication |
Parkinson's disease [ICD9: 332; ICD10:G20]
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C19H26ClNOS
|
| Canonical SMILES |
CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O.Cl
|
| InChI |
1S/C19H25NOS.ClH/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21;/h3-7,13,16,21H,2,8-12,14H2,1H3;1H/t16-;/m0./s1
|
| InChIKey |
CEXBONHIOKGWNU-NTISSMGPSA-N
|
| CAS Number |
CAS 125572-93-2
|
| PubChem Compound ID |
|
| PubChem Substance ID |
10259259, 16403358, 57395710, 77687306, 92718869, 93310552, 104431882, 126628418, 126651453, 126669923, 131296835, 134340447, 135158019, 152258943, 160647788, 162205071, 162247811, 164764901, 170485710, 176236870, 185980601, 196106216, 198958010, 198992559, 215782764, 223656922, 223865827, 228694817, 249855824, 252071693, 252157617, 252216229, 252430562
|
| Target and Pathway |
| Target(s) |
D(2) dopamine receptor |
Target Info |
Agonist |
[1]
|
|---|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Dopaminergic synapse
|
|
Parkinson's disease
|
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Cocaine addiction
|
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Alcoholism
|
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
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Reactome
|
Dopamine receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Genes and (Common) Pathways Underlying Drug Addiction
|
|
GPCR ligand binding
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GPCR downstream signaling
|
|
Nicotine Activity on Dopaminergic Neurons
|
| References |
| REF 1 | Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. |
|---|
