Drug Information

Drug General Information
Drug ID
D0E3UM
Former ID
DNC004565
Drug Name
L-657925
Synonyms
L-657926
Drug Type
Small molecular drug
Indication Discovery agent Terminated [544623]
Structure
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2D MOL

3D MOL
Formula
C21H21ClFNO2
Canonical SMILES
C1CC(C2=C(C1)C3=C(N2CC4=CC=C(C=C4)Cl)C=CC(=C3)F)CC(=O)O
InChI
1S/C21H19ClFNO2/c22-15-6-4-13(5-7-15)12-24-19-9-8-16(23)11-18(19)17-3-1-2-14(21(17)24)10-20(25)26/h4-9,11,14H,1-3,10,12H2,(H,25,26)/t14-/m0/s1
InChIKey
LHJWQVJJSYPRIX-AWEZNQCLSA-N
PubChem Compound ID
129772
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Inhibitor [529310]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 544623Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000341)
Ref 529310J Med Chem. 1991 Apr;34(4):1511-4.Novel synthesis and biochemical properties of an [125I]-labeled photoaffinity probe for thromboxane A2/prostaglandin H2 receptors.

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