Drug Information

Drug General Information
Drug ID
D0E0QT
Former ID
DNC005404
Drug Name
8-Nitro-6H,11H-indeno[1,2-c]isoquinolin-5-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527674]
Structure
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2D MOL

3D MOL
Formula
C16H10N2O3
Canonical SMILES
C1C2=C(C=C(C=C2)[N+](=O)[O-])C3=C1C4=CC=CC=C4C(=O)N3
InChI
1S/C16H10N2O3/c19-16-12-4-2-1-3-11(12)14-7-9-5-6-10(18(20)21)8-13(9)15(14)17-16/h1-6,8H,7H2,(H,17,19)
InChIKey
SWBDUXDIPMGDNO-UHFFFAOYSA-N
PubChem Compound ID
25190929
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [527674]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 527674J Med Chem. 2005 Aug 11;48(16):5100-3.Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.
Ref 527674J Med Chem. 2005 Aug 11;48(16):5100-3.Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.

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