Drug General Information
Drug ID
D0DX6L
Former ID
DIB010918
Drug Name
SDZ-PSD-958
Indication Psychiatric disorder [ICD9: 290-319; ICD10:F01-F99] Terminated [546576]
Company
Sandoz Pharma Ltd
Structure
Download
2D MOL

3D MOL

Canonical SMILES
N1([C@H]2[C@H](N(CC1)C)Cc1c(C2)c(O)ccc1)c1c(cc(cc1)Cl)C
CAS Number
CAS 149811-12-1
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Modulator [534179]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
References
Ref 546576Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009027)
Ref 534179SDZ PSD 958, a novel D1 receptor antagonist with potential limbic selectivity. J Neural Transm. 1996;103(3):261-76.

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