Drug General Information
Drug ID	D0DP8P
Former ID	DNC000367
Drug Name	BW755C
Drug Type	Small molecular drug
Indication	Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25]		Terminated	[534109]
Structure		Download 2D MOL 3D MOL
Formula	C10H10F3N3
Canonical SMILES	C1CN(N=C1N)C2=CC=CC(=C2)C(F)(F)F
InChI	1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
InChIKey	CPXGGWXJNQSFEP-UHFFFAOYSA-N
CAS Number	CAS 66000-40-6
PubChem Compound ID	47795
PubChem Substance ID	1995008, 4798294, 8180402, 12015705, 14773773, 34712751, 50070598, 50071207, 57313145, 78119914, 81656244, 91757133, 99222735, 103167028, 103857306, 103915088, 104353844, 105582736, 125695365, 127660739, 130887853, 134339811, 134349197, 135007807, 143305710, 162891670, 224097533, 225226571, 228672351, 249764864
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[536815]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 534109	BW755C, a dual lipoxygenase/cyclooxygenase inhibitor, reduces mural platelet and neutrophil deposition and vasoconstriction after angioplasty injury in pigs. J Pharmacol Exp Ther. 1996 Apr;277(1):17-21.
Ref 536815	Anti-inflammatory activity of Acanthus ilicifolius. J Ethnopharmacol. 2008 Oct 30;120(1):7-12. Epub 2008 Jul 25.

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