Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0DP8P
|
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| Former ID |
DNC000367
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| Drug Name |
BW755C
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| Drug Type |
Small molecular drug
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| Indication | Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C10H10F3N3
|
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| Canonical SMILES |
C1CN(N=C1N)C2=CC=CC(=C2)C(F)(F)F
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| InChI |
1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
|
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| InChIKey |
CPXGGWXJNQSFEP-UHFFFAOYSA-N
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| CAS Number |
CAS 66000-40-6
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| PubChem Compound ID | |||||
| PubChem Substance ID |
1995008, 4798294, 8180402, 12015705, 14773773, 34712751, 50070598, 50071207, 57313145, 78119914, 81656244, 91757133, 99222735, 103167028, 103857306, 103915088, 104353844, 105582736, 125695365, 127660739, 130887853, 134339811, 134349197, 135007807, 143305710, 162891670, 224097533, 225226571, 228672351, 249764864
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| Target and Pathway | |||||
| Target(s) | Arachidonate 5-lipoxygenase | Target Info | Inhibitor | [2] | |
| BioCyc Pathway | Aspirin-triggered lipoxin biosynthesis | ||||
| Resolvin D biosynthesis | |||||
| Leukotriene biosynthesis | |||||
| Lipoxin biosynthesis | |||||
| Aspirin triggered resolvin D biosynthesis | |||||
| Aspirin triggered resolvin E biosynthesis | |||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Toxoplasmosis | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Vitamin D Receptor Pathway | ||||
| Arachidonic acid metabolism | |||||
| Eicosanoid Synthesis | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | BW755C, a dual lipoxygenase/cyclooxygenase inhibitor, reduces mural platelet and neutrophil deposition and vasoconstriction after angioplasty injury in pigs. J Pharmacol Exp Ther. 1996 Apr;277(1):17-21. | ||||
| REF 2 | Anti-inflammatory activity of Acanthus ilicifolius. J Ethnopharmacol. 2008 Oct 30;120(1):7-12. Epub 2008 Jul 25. | ||||
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