Drug General Information
Drug ID	D0DN0W
Drug Name	Niraparib Tosylate
Synonyms	Zejula
Drug Type	Small molecular drug
Indication	Recurrent epithelial ovarian or primary peritoneal cancer [ICD10:C78]		Approved	[889446]
Company	Tesaro
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Modulator	[556264]
KEGG Pathway	Base excision repair
	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 889446	Drugs@FDA (Edaravone)
Ref 556264	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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