Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0DM6I
|
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| Former ID |
DIB010305
|
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| Drug Name |
DAPITANT
|
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| Drug Type |
Small molecular drug
|
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| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Phase 2 | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C37H39NO4
|
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| Canonical SMILES |
COc1ccccc1[C@H](C)C(=O)N2C[C@@H]3[C@H](C2)C(CC[C@@]3(O)<br />c4ccccc4OC)(c5ccccc5)c6ccccc6
|
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| InChIKey |
CCIWVEMVBWEMCY-RCFOMQFPSA-N
|
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| CAS Number |
CAS 153438-49-4
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Substance-P receptor | Target Info | Antagonist | [2], [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Measles | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Spinal Cord Injury | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Dapitant. RPR 100893. Drugs R D. 1999 Dec;2(6):383-4. | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004225) | ||||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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