Drug Information

Drug General Information
Drug ID
D0D9FV
Former ID
DAP000858
Drug Name
Orphenadrine
Synonyms
Antiflex; Biorphen; Brocadisipal; Brocasipal; Disipal; Lysantin; Mefenamine; Mephenamine; Methyldiphenylhydramine; Myolin; Myotrol; ORP; Orfenadrina; Orfro; Orphenadine; Orphenadinum; Orphenadrin; Orphenadrinum; Orphenate; Orphenedrine; Norflex Orphenadrine Citrate; Sodium Mefenamine; WS 2434; Banflex (TN); Biorphen (TN); Brocasipal (TN); Disipal (TN); Flexon (TN); Mephenamin (TN); Mialgin (TN); Mio-Rel; Norflex (TN); O-Methyldiphenhydramine; O-Monomethyldiphenhydramine; Orfenadrina [INN-Spanish]; Orphenadrine(INN); Orphenadrine [INN:BAN]; Orphenadrinum [INN-Latin]; Beta-Dimethylaminoethyl 2-methylbenzhydryl ether; Phenyl-o-tolylmethyl dimethyaminoethyl ether; Beta-Dimethylaminoethyl-2-methylbenzhydryl ether; N,N-Dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamin; N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine; N,N-dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamine; N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine; N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyl)oxy)ethylamine; N,N-Dimethyl-2-[(o-methyl-alpha-phenylbenzyl)oxy]ethylamine; N,N-dimethyl-2-{[(2-methylphenyl)(phenyl)methyl]oxy}ethanamine; 2-(Phenyl-o-tolylmethoxy)ethyldimethylamine; 2-Methyldiphenhydramine
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Approved [538173], [542269]
Therapeutic Class
Antiparkinson Agents
Company
3M Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C18H23NO
InChI
InChI=1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3
InChIKey
QVYRGXJJSLMXQH-UHFFFAOYSA-N
CAS Number
CAS 83-98-7
PubChem Compound ID
4601
PubChem Substance ID
10137, 3135863, 4696974, 7980208, 8152822, 10536817, 11135040, 11336028, 11361267, 11363939, 11366501, 11369063, 11371741, 11374019, 11377225, 11462239, 11466267, 11467387, 11484991, 11485974, 11488854, 11490347, 11492275, 11494859, 14750489, 26752323, 29223690, 46506085, 47216828, 47365247, 47662340, 47885466, 47959798, 47959799, 47959800, 48035183, 48334550, 48416355, 49698873, 49969196, 50105274, 53787260, 57322343, 75942199, 85209919, 85787502, 90341796, 96024992, 103235190, 103958137
SuperDrug ATC ID
M03BC01
SuperDrug CAS ID
cas=000083987
Target and Pathway
Target(s) NMDA receptor Target Info Antagonist [537076], [538036]
References
Ref 538173FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040249.
Ref 542269(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7251).
Ref 537076Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine. Pain. 2009 Apr;142(3):225-35. Epub 2009 Feb 12.
Ref 538036Dopamine/glutamate interactions in Parkinson's disease. Neurosci Biobehav Rev. 1997 Jul;21(4):393-400.

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