Drug General Information
Drug ID	D0D8YE
Former ID	DNC006351
Drug Name	3-(5-methoxy-1H-inden-2-yl)pyridine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528109]
Structure		Download 2D MOL 3D MOL
Formula	C15H13NO
Canonical SMILES	COC1=CC2=C(CC(=C2)C3=CN=CC=C3)C=C1
InChI	1S/C15H13NO/c1-17-15-5-4-11-7-13(8-14(11)9-15)12-3-2-6-16-10-12/h2-6,8-10H,7H2,1H3
InChIKey	KPJYOCDWGFDTFR-UHFFFAOYSA-N
PubChem Compound ID	6540048
Target and Pathway
Target(s)	Cytochrome P450 11B1, mitochondrial	Target Info	Inhibitor	[528109]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Glucocorticoid biosynthesis
	Mineralocorticoid biosynthesis
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
PathWhiz Pathway	Steroidogenesis
Reactome	Glucocorticoid biosynthesis
	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Oxidation by Cytochrome P450
	Metabolism of steroid hormones and vitamin D
	Corticotropin-releasing hormone
References
Ref 528109	J Med Chem. 2006 Apr 6;49(7):2222-31.Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.
Ref 528109	J Med Chem. 2006 Apr 6;49(7):2222-31.Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.

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