Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D7XW
|
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| Former ID |
DIB000927
|
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| Drug Name |
SINITRODIL
|
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| Synonyms |
ITF-296; Sinitrodil < Prop INN >; 3-[2-(Nitrooxy)ethyl]-2H-1,3-benzoxazin-4(3H)-one
|
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| Drug Type |
Small molecular drug
|
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| Indication | Angina pectoris [ICD9: 413; ICD10:I20] | Discontinued in Phase 2 | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C10H10N2O5
|
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| Canonical SMILES |
[O-][N+](=O)OCCN1COc2ccccc2C1=O
|
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| InChI |
1S/C10H10N2O5/c13-10-8-3-1-2-4-9(8)16-7-11(10)5-6-17-12(14)15/h1-4H,5-7H2
|
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| InChIKey |
POVFCWQCRHXYAB-UHFFFAOYSA-N
|
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| CAS Number |
CAS 143248-63-9
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | CGMP-specific 3',5'-cyclic phosphodiesterase | Target Info | Modulator | [2] | |
| KEGG Pathway | Purine metabolism | ||||
| cGMP-PKG signaling pathway | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| Reactome | cGMP effects | ||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005482) | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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