Drug Information

Drug General Information
Drug ID
D0D7KC
Former ID
DAP001140
Drug Name
Alvimopan
Synonyms
Alvimopan anhydrous; LY 246736; LY246736; Adl 8-2698; Entereg (TN); Trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine; Glycine, N-[2-[[4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl; 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid
Drug Type
Small molecular drug
Indication Gastrointestinal disease; Pain [ICD9: 338, 356.0, 356.8, 780; ICD10:K00-K93, G64, G90.0, R52, G89] Approved [529941], [536527], [542496]
Therapeutic Class
Analgesics
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C25H32N2O4
InChI
InChI=1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1
InChIKey
UPNUIXSCZBYVBB-JVFUWBCBSA-N
CAS Number
CAS 156053-89-3
PubChem Compound ID
5488548
PubChem Substance ID
11694298, 14782746, 14929630, 39473631, 57364430, 75544615, 93619728, 99443242, 103572184, 104179178, 113996613, 126574462, 126724760, 134224030, 135111682, 136008678, 137005188, 137445067, 152035895, 152258482, 160647317, 160967857, 162185566, 163125717, 163416638, 163884570, 164777755, 164826629, 175267928, 180371296, 184816790, 187051774, 204380366, 223554824, 226433297, 241036441, 249858481, 249865158, 250216916, 251916104, 251917452, 252075803, 252432676
SuperDrug ATC ID
A06AH02
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Antagonist [537576]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
Ref 536527Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007 Nov;12(4):619-26.
Ref 542496(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7471).
Ref 537576Alvimopan for postoperative ileus. Am J Health Syst Pharm. 2009 Jul 15;66(14):1267-77.

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