Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D6ZB
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| Former ID |
DIB002472
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| Drug Name |
AX-9657
|
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| Synonyms |
AX-9657; Neutrophil elastase inhibitors (lung disease); HNE inhibitors (lung disease), Kyorin; Neutrophil elastase inhibitors (lung disease), Kyorin
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| Drug Type |
Small molecular drug
|
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| Indication | Pulmonary disease [ICD9: 460-519; ICD10:J00-J99] | Investigative | [1] | ||
| Company |
Kyorin Pharmaceutical Co Ltd
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| Structure |
|
Download2D MOL |
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| Formula |
C22H26N4O3
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| Canonical SMILES |
[C@@H]1(N(C)C)CN(c2c(c3nc4cc(cc(c4c(=O)o3)CC)OC)cccn2)C<br />C1
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Leukocyte elastase | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Transcriptional misregulation in cancer | ||||
| Systemic lupus erythematosus | |||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | ||||
| C-MYB transcription factor network | |||||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
| Human Complement System | |||||
| Degradation of collagen | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2358). | ||||
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