Drug Information

Drug General Information
Drug ID
D0D6MH
Former ID
DIB019981
Drug Name
GW-2580
Synonyms
GW2580; cFMS receptor tyrosine kinase inhibitor; GW632580X
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527820]
Structure
Download
2D MOL
Formula
C20H22N4O3
InChI
InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
InChIKey
MYQAUKPBNJWPIE-UHFFFAOYSA-N
PubChem Compound ID
11617559
PubChem Substance ID
16720475, 23726246, 26758710, 50100101, 53800773, 79254755, 99302679, 103567703, 103905623, 124349955, 134352694, 134353091, 137355269, 143472530, 162012043, 163123671, 163688133, 163779908, 170484718, 172087029, 172650488, 172652491, 175607408, 176485314, 178102312, 180372393, 186006545, 189158925, 198950783, 204377784, 208264983, 208265629, 215778467, 223573728, 223843997, 230266506, 242059754, 247419869, 252215520, 252451474, 252553667, 252615797
Target and Pathway
Target(s) mRNA of Colony stimulating factor-1 receptor Target Info Inhibitor [527820]
NetPath Pathway TCR Signaling Pathway
Notch Signaling Pathway
Pathway Interaction Database Signaling events mediated by PTP1B
Signaling events mediated by TCPTP
Integrins in angiogenesis
C-MYB transcription factor network
References
Ref 527820Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83. Epub 2005 Oct 25.
Ref 527820Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83. Epub 2005 Oct 25.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.