Drug Information

Drug General Information
Drug ID
D0D4XF
Former ID
DNC000516
Drug Name
Daniplestim
Indication Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890] Terminated [546034]
CAS Number
CAS 59277-89-3
PubChem Substance ID
17397745
ChEBI ID
ChEBI:2453
SuperDrug ATC ID
D06BB03
SuperDrug CAS ID
cas=059277893
Target and Pathway
Target(s) Interleukin 3 receptor Target Info Agonist [535051]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Apoptosis
Jak-STAT signaling pathway
Hematopoietic cell lineage
NetPath Pathway IL5 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database IL3-mediated signaling events
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways IL-3 Signaling Pathway
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
References
Ref 546034Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005988)
Ref 535051The combined administration of daniplestim and Mpl ligand augments the hematopoietic reconstitution observed with single cytokine administration in a nonhuman primate model of myelosuppression. Stem Cells. 1998;16 Suppl 2:143-54.

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